Sheng-Chih ChuKikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign and self-limited disease. Enlargement of lymph nodes with pain is a common manifestation of KFD especially within the cervical region. However, the etiology and management of this disease are still relatively uncertain. Therefore, KFD is easily misdiagnosed or missed. I present a case of an 8-year-old boy who presented to our pediatric emergency department with a 2-week history of prolonged fever and painful neck mass previously had been treated with antibiotics at clinic. KFD was diagnosed after lymph node biopsy and he recovered under supportive treatment.